Antibiotics for Covid Cases Worsen India’s Superbug Crisis

via Bloomberg

Excessive use of the world’s most potent antibiotics has stoked drug-resistant infections in India for years. Now the country’s Covid crisis has put the calamity into hyperdrive.

A first look at how many patients hospitalized during India’s first coronavirus wave also developed bacterial and fungal infections found that a small but alarming proportion harbor germs that resist multiple drugs.

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Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology

via National Library of Medicine

The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both basic and applied research fields but always with the aim of improving our understanding of human disease.

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Comparative Molecular Analysis of Testicular Leydig Cell Tumors Demonstrates Distinct Subsets of Neoplasms with Aggressive Histopathologic Features

via Modern Pathology

Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5–10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with clinically aggressive tumors. From a molecular perspective, the characteristics of aggressive LCTs and the differences between aggressive and nonaggressive LCTs remain largely unexplored.

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Global Shortage of Innovative Antibiotics Fuels Emergence and Spread of Drug-Resistance

via World Health Organization

The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world’s most dangerous bacteria…

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