https://www.korpath.com/wp-content/uploads/blog_molecules-1.jpg 500 900 Tom https://www.korpath.com/wp-content/uploads/weblogo_main-2.jpg Tom2021-05-19 16:25:452021-06-24 16:43:30Comparative Molecular Analysis of Testicular Leydig Cell Tumors Demonstrates Distinct Subsets of Neoplasms with Aggressive Histopathologic Features
Comparative Molecular Analysis of Testicular Leydig Cell Tumors Demonstrates Distinct Subsets of Neoplasms with Aggressive Histopathologic Features
via Modern Pathology
Testicular Leydig cell tumor (LCT), the most common sex-cord stromal tumor in men, represents a small fraction of all testicular tumors (~1 to 3%). Although most testicular LCTs are indolent and cured by radical orchiectomy, 5–10% have aggressive biology and metastatic potential. In primary LCTs, large size, cytologic atypia, necrosis, increased mitotic activity, and vascular invasion have been associated with clinically aggressive tumors. From a molecular perspective, the characteristics of aggressive LCTs and the differences between aggressive and nonaggressive LCTs remain largely unexplored.